HORDB

ID: hor004655
Uniprot ID: Q8LDN4
Protein name: CLAVATA3/ESR (CLE)-related protein 46
Gene name: CLE46
Organism: Arabidopsis thaliana (Mouse-ear cress)
Family: CLV3/ESR signal peptide family
Source: Plant
Expression: NA
Disease: NA
Comments: NA
Taxonomy: Arabidopsis (genus), Camelineae (tribe), Brassicaceae (family), Brassicales (order), malvids, rosids, Pentapetalae, Gunneridae, eudicotyledons, Mesangiospermae, Magnoliopsida (class), Spermatophyta, Euphyllophyta, Tracheophyta, Embryophyta, Streptophytina (subphylum), Streptophyta (phylum), Viridiplantae (kingdom), Eukaryota (superkingdom), cellular organisms
GO MF: NA
GO BP: GO:0030154 cell differentiation; GO:0045168 cell-cell signaling involved in cell fate commitment
GO CC: GO:0005576 extracellular region

Sequence: QEVHFKIGPAKIIAKPNNARVMPTWGEEKKWHKHPSGPNPTGNRHPPVKH
Length: 50
Propeptide: MRRHDIIIKLLLLMCLLLSRFVTRECQEVHFKIGPAKIIAKPNNARVMPTWGEEKKWHKHPSGPNPTGNRHPPVKH
Signal peptide: MRRHDIIIKLLLLMCLLLSRFVTREC
Modification: T35 Hydroxyproline;T38 Hydroxyproline
Glycosylation: T38 O-linked (Ara...) hydroxyproline
Mutagenesis: NA

Function: Extracellular signal peptide that regulates cell fate. {ECO:0000250}.
Mechanism: NA
Cross BBB: NA
Target: NA
Target Unid: NA
IC50: NA
EC50: NA
ED50: NA
kd: NA
Half life: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor004655_AF2.pdb

hor004655_ESM.pdb

Mass:	655471	Formula:	C257H398N80O65S
Absent amino acids:	CDLY	Common amino acids:	PK
pI:	11.17	Basic residues:	14
Polar residues:	11	Hydrophobic residues:	12
Hydrophobicity:	-125	Boman Index:	-10700
Half-Life:	0.8 hour	Half-Life Yeast:	10 min
Half-Life E.Coli:	>10 hour	Aliphatic Index	46.8
Instability Index:	3542	Extinction Coefficient cystines:	11000
Absorbance 280nm:	224.49